City of Hope National Medical Center, (commonly City of Hope) is a private, not-for-profit clinical research center, hospital and graduate medical school located in Duarte, California, United States. The center’s main campus resides on 110-acres of land adjacent to the boundaries of Duarte and Irwindale, California, with satellite offices in Monrovia, California and downtown Los Angeles, California, and regional fundraising offices throughout the country. City of Hope Cancer Center